This web page was produced as an assignment for Genetics 564, an undergraduate course at UW-Madison.
the PSEN1 gene
PSEN1, the gene directly involved in producing the PSEN1 protein is proven essential to developing Alzheimer's Disease. Found on human chromosome 14, several single nucleotide deletions in the PSEN1 gene is responsible for overproduction of a toxic amyloid peptide, the amyloid precursor protein (APP) which in turn results in brain neurodegradation [1]. This degradation is the focus of many Alzheimer's research projects, including this one.
Information gathered on the PSEN1 gene consists of homology and gene ontology. For more information either of these topics, follow one of the links below:
PSEN1 Homology
PSEN1 Gene Ontology
Information gathered on the PSEN1 gene consists of homology and gene ontology. For more information either of these topics, follow one of the links below:
PSEN1 Homology
PSEN1 Gene Ontology
PSEN1 Genetic Information
When referencing genes, several important pieces of information are noted, namely the accession number, the genetic transcript and the FASTA sequence. Together, this series allows for further interpretation and extrapolation of genetic data, but also allows various aspects of research to be conducted. In this case, the data below was utilized in producing gene homology and gene ontology for PSEN1. For any of the necessary information, follow one of the links below:
REFERENCES
Cover Photo: obtained from http://guardianlv.com/2014/07/gene-therapy-benefits-and-potential risks/
[1] De Strooper, B. (2007). Loss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer disease.EMBO Reports, 8(2), 141–146. doi:10.1038/sj.embor.7400897
[1] De Strooper, B. (2007). Loss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer disease.EMBO Reports, 8(2), 141–146. doi:10.1038/sj.embor.7400897