This web page was produced as an assignment for Genetics 564, an undergraduate course at UW Madison.
presenilin 1 gene and protein
Following the central dogma of molecular biology, DNA is transcribed into RNA, which is then translated into various proteins [1]. This classic, biological protocol describes what must be known in order to properly understand a genetic disease and the observed disease phenotypes. As such, for Alzheimer's disease, information must be collected on both the presenilin 1 gene (PSEN1) and the presenilin 1 protein (PSEN1). Through the central dogma, both of these play an increasingly crucial role in Alzheimer's research. For information regarding either PSEN1 or PSEN1, follow one of the links below:
PSEN1 Gene
PSEN1 Protein
PSEN1 Gene
PSEN1 Protein
genetic Research
Once data regarding both genes and proteins are gathered, various types of research can take place. Though there are several different tools for genetic research, the ones focused in this project refer to the utilizable presenilin 1 model organisms, such as mice, rats and zebrafish, transcriptomics and RNA interference, and chemical genetics [2]. Through these approaches, conclusive evidence can be presented and interpreted to produce various specific aims for the research. Conclusively, these specific aims should indicate what direction the future of Alzheimer's--and other genetic diseases--research should head in.
For information regarding the research tools utilized in this research project, the composed specific aims, or the future directions and conclusions regarding Alzheimer's and presenilin 1, follow one of the links below:
Research Tools
Specific Aims
Future Directions and Conclusions
For information regarding the research tools utilized in this research project, the composed specific aims, or the future directions and conclusions regarding Alzheimer's and presenilin 1, follow one of the links below:
Research Tools
Specific Aims
Future Directions and Conclusions
REFERENCES
Cover Photo: obtained from http://thisisartlab.com/tag/central-dogma/
[1] "Central Dogma of Biology." NCBI. U.S. National Library of Medicine, 05 Nov. 2007. Web. 26 Mar. 2015 <http://www.ncbi.nlm.nih.gov/Class/MLACourse/Modules/MolBioReview/central_dogma.html>.
[2] Young, Susan. "Genome Surgery." MIT Technology Review. N.p., 11 Feb. 2014. Web. 26 Mar. 2015. <http://www.technologyreview.com/review/524451/genome-surgery/>.
[1] "Central Dogma of Biology." NCBI. U.S. National Library of Medicine, 05 Nov. 2007. Web. 26 Mar. 2015 <http://www.ncbi.nlm.nih.gov/Class/MLACourse/Modules/MolBioReview/central_dogma.html>.
[2] Young, Susan. "Genome Surgery." MIT Technology Review. N.p., 11 Feb. 2014. Web. 26 Mar. 2015. <http://www.technologyreview.com/review/524451/genome-surgery/>.